Molecular basis of Huntington's disease and brain imaging evidence

Autor:	Antonia Plerou, Catherine Bobori, Panayiotis Vlamos
Rok vydání:	2015
Předmět:	medicine.diagnostic_test business.industry Disease Electroencephalography medicine.disease Brain mapping Neuroimaging Huntington's disease Mutant protein Basal ganglia Huntingtin Protein Medicine business Neuroscience
Zdroj:	ISSPIT
DOI:	10.1109/isspit.2015.7394365
Popis:	Huntington's disease as a neurodegenerative disease is characterized by motor and cognitive impairment. The disease is caused by the mutation of the gene that produces the huntingtin protein causing the repetition of trinucleotide CAG. The mutant protein reacts with other proteins inside and out of the cell causing problems to its normal function and cell death. Recent advances in the signal analysis have engendered EEG with the status of a true brain mapping and brain imaging method able of providing spatio-temporal information regarding brain (dys)function. Authors aim to review objectively and quantitatively the neurophysiological basis of the disease in HD patients as compared to normal controls, with the use of brain imaging in general and EEG brain imaging methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::699df5af7253d238a94693672991d7e2 https://doi.org/10.1109/isspit.2015.7394365 Zobrazit plný text záznamu