The Protective Effect of SARS-CoV-2 Antibodies in Scottish Healthcare Workers

Autor: Stephanie Gallant, Rachel Strachan, Yan Hui Giam, Gordon Hay, Beth Marshall, Elizabeth Furrie, Thomas Pembridge, Caroline Snowdon, Hani Abo-Leyah, Justin Killick, James D. Chalmers, Diane Cassidy, Natalie Gallant, Benjamin J. Parcell, Eleanor J Hothersall
Rok vydání: 2021
Předmět:
Zdroj: SSRN Electronic Journal.
ISSN: 1556-5068
Popis: Background: Healthcare workers (HCW) are believed to be at increased risk of SARS-CoV-2 infection. The extent of that increased risk compared to the general population and the groups most at risk have not been extensively studied. It is also not known to what extent the natural production of antibodies to SARS-CoV-2 is protective against re-infection. Methods: A prospective observational study of health and social care workers in NHS Tayside (Scotland, UK) from May to September 2020. The Siemens SARS-CoV-2 total antibody assay was used to establish seroprevalence in this cohort. Controls, matched for age and sex to the general Tayside population, were studied for comparison. New infections post antibody testing were recorded to determine if the presence of SARS-CoV-2 antibodies protect against re-infection. Results: A total of 2063 health and social care workers were recruited for this study. 300 HCW had a positive antibody test (14.5%). 11/231 control sera tested positive (4.8%). HCW therefore had an increased likelihood of a positive test (Odds ratio 3.4 95% CI 1.85-6.16, p
Databáze: OpenAIRE