| Autor: |
Jesse Z. Dong, Jeffrey Lauer, Isabelle Viossat, Philip G. Kasprzyk, Marie C. Brezak, Barry A. Morgan, Gregoire Prevost, M-Odile Lonchampt, Christine Le Breton, Mark Carlson |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Peptides for the New Millennium ISBN: 9780792364450 |
| DOI: |
10.1007/0-306-46881-6_182 |
| Popis: |
Mutated ras genes are implicated in 20-30% of all human tumors, including 50% of colon, 30% of lung and 90% of pancreatic cancer [1,2]. The Ras protein is initially synthesized as an inactive cytosolic precursor that requires a series of posttranslational modifications in order to associate to the cell membrane and perform its normal and oncogenic functions. The key step in these modifications is farnesylation of a cysteine residue in the C-terminal motif of the Ras protein. Since this prenylation is catalyzed by farnesyl-protein transferase (FTase), inhibition of FTase should indirectly regulate oncogenic ras function. Therefore, inhibitors of FTase represent potential anticancer agents. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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