Circadian leptin, insulin and cortisol rhythms in obese subjects
| Autor: | Zouhaier Tabka, Abdelkarim Zbidi, Larbi Chaieb, Nada Dallel, Molka Chaieb, Monia Zaouali, Taheni Ben Lazreg |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry Leptin Insulin medicine.medical_treatment digestive oral and skin physiology Serum samples medicine.disease Obesity Rhythm Endocrinology Physiology (medical) Internal medicine Medicine Obese subjects Leptin resistance Circadian rhythm business hormones hormone substitutes and hormone antagonists Ecology Evolution Behavior and Systematics |
| Zdroj: | Biological Rhythm Research. 38:9-17 |
| ISSN: | 1744-4179 0929-1016 |
| DOI: | 10.1080/09291010600831380 |
| Popis: | The recent discovery of leptin, the product of the “ob” gene has greatly advanced the understanding of body adiposity and energy balance regulation. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by insulin increases levels and the circadian rhythm of cortisol. The aims of this study were to: (1) determine the effect of obesity on leptin 24 hours pattern; (2) determine the biological rhythm of leptin, insulin and cortisol. Thirteen subjects (10 women, three men) participated in this study. Serum samples were drawn at four hour intervals for a total of 24 hours. Leptin showed diurnal rhythmicity with peaks at 04.00 h (91.7±12.9 ng/ml) and troughs at 12.00 h (73.1±9.7 ng/ml). There was a strong association between leptin levels and BMI (r = 0.34; p |
| Databáze: | OpenAIRE |
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