Synthesis of several new isoxazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, benzoxadiazine and benzothiazine derivatives from hydroximoyl halides

Autor:	Abdou O. Abdelhamid, Sayed A. Mahgoub, Sadek Elsayed Abdou
Rok vydání:	1992
Předmět:	Pyrimidine Thiophenol Organic Chemistry Benzothiazine Medicinal chemistry chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Pyridine Molecular Medicine Organic chemistry Isoxazole Methylene Acrylonitrile
Zdroj:	Archives of Pharmacal Research. 15:317-321
ISSN:	1976-3786 0253-6269
DOI:	10.1007/bf02974105
Popis:	Furoylhydroximoyl chloride3 reacted with 2-aminopyridine, 2-aminopyrimidine,O-aminophenol,O-phenylenediamine and aminothiophenol to afford imidazo[1,2-a]pyridine6, imidazo[1,2-a]pyrimidine8, benzoxadiazine10, nitrosobenzopyrazine13a and nitrosobenzothiazine13b, respectively. Isoxazoline18 and pyrrolidino[3,4-d]isoxazolin-4,6-dione derivatives19a and19b obtained by the reaction of3 with acrylonitrile and N-arylmaleimide. Hydroximoyl chloride3 reacted with thiophenol and sodium benzenesulfinate to yield furylglyoxaloxime16a and16b, respectively. Hydroximoyl chloride3 reacted also with some active methylene compound to give isoxazole derivatives20–23, respectively.
Databáze:	OpenAIRE
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