Monophasic synovial sarcoma of the lower extremity at 20 weeks of pregnancy: a case report and review of the literature
| Autor: | P. Bielikova, Iva Staniczková Zambo, H. Svebisova, K. Huml, V. Prasil, B. Melichar, Pavel Janíček, R. Pilka, J. Jankova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Pregnancy Adjuvant chemotherapy business.industry medicine.medical_treatment Incidence (epidemiology) Obstetrics and Gynecology Malignancy medicine.disease Synovial sarcoma Surgery Reproductive Medicine Monophasic Synovial Sarcoma medicine Caesarean section Doxorubicin business medicine.drug |
| Zdroj: | Clinical and Experimental Obstetrics & Gynecology. 46:992-998 |
| ISSN: | 0390-6663 |
| DOI: | 10.12891/ceog4877.2019 |
| Popis: | Introduction: The incidence of malignancy in pregnancy is reported to range approximately between 0.02% and 1%. Synovial sarcoma (SS) is a rare aggressive mesenchymal tumor for which there are no treatment guidelines during pregnancy. Case Report: The authors report a 23-year-old primigravida presenting. at 20+0 weeks of pregnancy. with a growing painful mass in the left thigh. The diagnosis of monophasic SS grade 3 was confirmed by the presence of SYT gene fusion. On MRI scan there was a heterogeneous localized mass of size 75 x115 x103 mm, but there was no evidence of distant metastases. Limb-sparing surgery with clear-surgical margins was performed at 26+3 weeks of pregnancy. Adjuvant chemotherapy with two cycles of doxorubicin was followed by delivery of normal child by caesarean section at 36+3 weeks of pregnancy. Adjuvant radiotherapy of total dose of 66 Gray to the site of the resection had been administered followed by two cycles of doxorubicin. Conclusion: The patient is free of recurrence six months after the completion of the treatment. |
| Databáze: | OpenAIRE |
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