The simultaneous spectrophotometric determination of trimazolin and phenylephrine hydrochloride in nasal preparations

Autor:	Goran Nikolić, Ivan M. Savic, Vladimir Bankovic, Ivana M. Savic
Rok vydání:	2008
Předmět:	Accuracy and precision Aqueous solution Chromatography Resolution (mass spectrometry) Chemistry General Chemical Engineering Relative standard deviation Extraction (chemistry) Analytical chemistry NASAL PREPARATIONS Phenylephrine Hydrochloride Molar absorptivity
Zdroj:	Chemical Industry and Chemical Engineering Quarterly. 14:261-264
ISSN:	2217-7434 1451-9372
DOI:	10.2298/ciceq0804261s
Popis:	This paper presents the experimental results for the simultaneous spectrophotometric determination of two active components in nasal solutions. The resolution of two-component mixtures of timazolin and phenylephrine has been accomplished by using partial least-squares. The method comprised of the absorptivity measurement in a nasal solution at wavelengths of 265 and 272 nm, respectively. Notwithstanding the presence of two components and their high degree of spectral overlap, they have been determined simultaneously with high accuracy and precision, with no interference, rapidly and without resorting to extraction procedures using non aqueous solvents. This method was tested and validated for various parameters according to ICH guidelines. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::695d4945a4d602717812d59313696999 https://doi.org/10.2298/ciceq0804261s Zobrazit plný text záznamu