Cytotoxicity of Conjugates of 188Re-Labeled Dendrimers and Monoclonal Antibodies Anti-ICO-25 (MUC1) and Anti-ICO-80 (CD5) Against SKOV-3 (Ovary Cancer) and Jurkat Tumor Cell Lines (T-Lymphoblstic Lymphoma)
| Autor: | A. V. Smirnova, E. Yu. Grigor’eva, Yu. V. Stukalov, V. N. Kulakov, N. S. Kalygina, E. Yu. Koldaeva, A. Yu. Baryshnikov |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology biology Chemistry medicine.drug_class medicine.medical_treatment medicine.disease Monoclonal antibody Jurkat cells Lymphoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Radioimmunotherapy Drug Discovery medicine biology.protein Cancer research CD5 Antibody Cytotoxicity MUC1 |
| Zdroj: | Pharmaceutical Chemistry Journal. 52:681-684 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | Targeted radioimmunotherapy is a promising approach to radiotherapy. Tumor-specific compounds were synthesized using monoclonal antibodies anti-ICO-25 (MUC1) and anti-ICO-80 (CD5) labeled with the therapeutic radioisotope 188Re. The specificity of the conjugates was demonstrated in vitro using SKOV-3 (ovary cancer) and Jurkat tumor cell lines (T-lymphoblastic lymphoma), which are known to have membrane surface receptors specific for the corresponding antibodies. Short-term survival tests revealed 90-93% death of tumor cells, indicating the proposed conjugates were promising for targeted delivery of diagnostic and therapeutic cancer drugs. |
| Databáze: | OpenAIRE |
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