X-Ray analysis of 6-ethoxycarbonyl-4-ethylpyrazolo[1,5-a]pyrimidin-7(4H)-one and 6-ethoxycarbonyl-4-ethyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one

Autor:	Norman H. Rogers, Victoria J. Smith, J. Peter Clayton, Trevor J. King, Robert Stevenson
Rok vydání:	1980
Předmět:	Diethyl ethoxymethylenemalonate chemistry.chemical_compound chemistry Pyrimidine Product (mathematics) Ethyl iodide Organic chemistry X ray analysis Medicinal chemistry Derivative (chemistry)
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :1347
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19800001347
Popis:	The product obtained by treating 6-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine (2a) with ethyl iodide is shown by X-ray analysis to be 6-ethoxycarbonyl-4-ethylpyrazolo[1,5-a]pyrimidin-7(4H)-one (3a). When 3-amino-1,2,4-triazole (5a) was cyclised with diethyl ethoxymethylenemalonate the product was shown to have the structure (2b), rather than (6), by an X-ray analysis of its N-ethyl derivative, 6-ethoxycarbonyl-4-ethyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one (3d). Carbon-13 chemical shift values in the above and related compounds have been assigned.
Databáze:	OpenAIRE
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