| Popis: |
Background Sex hormones, especially estrogen, which binds to estrogen receptor β (ERβ), play a vital role in the pathogenesis of mental disorders such as autism spectrum disorder (ASD). The purpose of this study was to analyze the serum levels of hormone receptors, including ERβ, progesterone receptor (PGR) and androgen receptor (AR), and compare these levels between children with ASD and typically developing (TD) children. We also investigated the relationships of ERβ mRNA levels with ASD core symptoms, sleep, and developmental quotients (DQs) from the Gesell Developmental Schedules (GDS) among children with ASD. Methods We compared the mRNA levels of ERβ, AR, and PGR between 56 children with ASD and 37 TD children by using quantitative real-time PCR. Then, a correlation analysis was performed to determine the correlations of ERβ mRNA levels with Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC), and Children’s Sleep Habits Questionnaire (CHSQ) scores as well as DQs among ASD children. Results We found that serum mRNA levels of ERβ in ASD children were significantly lower than those in the TD group. However, we found no correlations of the ERβ mRNA level with CARS, ABC, and CHSQ scores as well as DQs on each GDS domain among ASD children. Conclusions Elevated ERβ mRNA levels in peripheral blood may be related to ASD but this association needs to be validated with a larger sample size. |
