An Investigation of the Reuse of Liquid Membranes and the Use of a Multidrug Donor Phase in Solute Transport

Autor:	Christopher T. Rhodes, Andrea Panaggio
Rok vydání:	1984
Předmět:	Pharmacology Drug Chromatography Chemistry media_common.quotation_subject Organic Chemistry Pharmaceutical Science Drug uptake chemistry.chemical_compound Membrane Phase (matter) Drug Discovery Emulsion Drug delivery Pharmaceutics Salicylic acid media_common
Zdroj:	Drug Development and Industrial Pharmacy. 10:623-635
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639048409041411
Popis:	Complex or multiple emulsions have been investigated for their potential use in pharmaceutics as both drug delivery and drug removal systems. Studies involving previously unused emulsions and single drug donor phases have been described in the literature. The subsequent uptake of solutes using one multiple emulsion or liquid membrane and the co-uptake of solutes from one donor phase were studied. The ability of liquid membranes to remove one solute following removal of another solute was studied for three systems using salicylic acid and phenobarbital at various temperatures. In each case it was observed that the liquid membrane was capable of subsequent drug uptake to varying degrees indicating that the previous use of liquid membranes does not materially affect their further use as sinks. The removal of two drugs from one donor phase using a liquid membrane was studied using acetylsalicylic acid, salicylic acid, and phenobarbital. These systems demonstrated the ability to remove two solutes simu...
Databáze:	OpenAIRE
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