In-silico Ligand and Structure Based Design of HIV-1 Protease Inhibitors: Current Trends and Future Directions
| Autor: | Ramasamy S., Sushmita Gupta, Ritu Rani Chaudhary, Amit Kumar Verma |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Research Journal of Pharmacy and Technology. :1477-1482 |
| ISSN: | 0974-360X 0974-3618 |
| Popis: | A study of the function of the protease inhibitor as well as of highly active antiretroviral therapy is involved in the present work. The paper focused on the cause of drug resistance and related phenomena, the HIV protease structure and its catalytic mechanism, the production of HIV inhibitors based on CADD, as well as ligand-based drug design using QSAR and computational binding energy technique, other computational modelling, optimization based on CORAL software. In order to shed light on the potential growth of the new drug for the treatment of HIV, the debate on the prediction of the desired biological activity and the structural relationship studies and study related to the structure-based drug design and the most potent drugs was reviewed. |
| Databáze: | OpenAIRE |
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