| Popis: |
Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (p |
