Fluorescent Angiotensin AT1Receptor Antagonists

Autor:	Michelle K. Taylor, Carl H. Schiesser, James Ziogas, Marilena A. Giarrusso, Phoebe E. Macdougall, Kate M. Brody
Rok vydání:	2012
Předmět:	Anthracene chemistry.chemical_compound Angiotensin II receptor type 1 chemistry Biochemistry Cellular imaging Chinese hamster ovary cell Organic Chemistry Renin–angiotensin system Acenaphthene Coumarin Fluorescence
Zdroj:	Asian Journal of Organic Chemistry. 1:274-279
ISSN:	2193-5807
DOI:	10.1002/ajoc.201200064
Popis:	Fluorescent selective angiotensin AT1 receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6–15 proved to be effective sartans with pKB estimates in the range of 6.7–10.5; their potential as cellular imaging agents is also discussed.
Databáze:	OpenAIRE
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