Synthesis and antibacterial activity of novel chalcone derivatives bearing a coumarin moiety
| Autor: | Jiang Shichun, Guo Tao, Ying Chen, Yihui Wang, Wei Xue, Xu Tang, Ming He, Xia Rongjiao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ralstonia solanacearum
Chalcone biology Chemistry Stereochemistry General Chemical Engineering 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification Coumarin 01 natural sciences Biochemistry Industrial and Manufacturing Engineering 0104 chemical sciences chemistry.chemical_compound Xanthomonas oryzae Materials Chemistry Proton NMR Moiety 0210 nano-technology Antibacterial activity Antibacterial agent |
| Zdroj: | Chemical Papers. 73:2493-2500 |
| ISSN: | 1336-9075 2585-7290 |
| DOI: | 10.1007/s11696-019-00802-0 |
| Popis: | A series of novel chalcone derivatives, that bear a coumarin moiety, were designed and synthesized, and their structures were confirmed via 1H NMR, 13C NMR, and H RMS. The bioassay results indicated that most title compounds exhibited remarkable antibacterial effects. Notably, compound 3a presented the most efficient antibacterial activity against Xanthomonas oryzae pv. Oryzae (Xoo), with median effect concentration (EC50) value of 49.77 μg/mL, which was far preferable than that of thiodiazole–copper (179.93 μg/mL). Meanwhile, compound 3n was identified as the best potential antibacterial agent against Xanthomonas axonopodis pv. citri (Xac), with EC50 value of 48.04 μg/mL, which far surpassed that of thiodiazole–copper (162.48 μg/mL). Furthermore, compound 3i indicated excellent antibacterial activity against Ralstonia solanacearum (Rs), with EC50 value of 65.04 μg/mL, which was far superior to that of thiodiazole–copper (126.89 μg/mL). This study indicated that chalcone hybrids, bearing a coumarin moiety, are worthy of further investigation as potential antibacterial drugs. |
| Databáze: | OpenAIRE |
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