Inhibition of leucocyte migration: A mechanism of anti-inflammatory effect of the ethanol extract of the stem bark of Alstonia boonei in Wistar rats
| Autor: | Christian E. Odo, Osmund C. Enechi, Onyedika N. Onyekwelu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Stem bark
Ethanol Traditional medicine business.industry ved/biology medicine.drug_class medicine.medical_treatment ved/biology.organism_classification_rank.species Body weight complex mixtures Anti-inflammatory chemistry.chemical_compound chemistry Immunology Medicine business Alstonia boonei Inhibitory effect Saline Leucocyte migration |
| Zdroj: | Journal of Pharmacy Research. 6:925-927 |
| ISSN: | 0974-6943 |
| DOI: | 10.1016/j.jopr.2013.09.005 |
| Popis: | Background and aim: The stem bark of Alstonia boonei is used in traditional medicine to treator reduce inflammation and pain in Nigeria. In view of these, the effect of the ethanolextract of its stem bark on agar-induced leucocyte migration in rats as a mechanism ofanti-inflammation was investigated.Methods: The effect of the ethanol extract of the stem bark of A. boonei on agar-inducedleucocyte migration in rats was evaluated using standard analytical method.Results: The results showed significant (p < 0.05) inhibitions of leucocyte migrations in therats administered 400, 800 and 1200 mg/kg body weight (b. w) compared to the leucocytemigration of the rats in the control group (5 ml/kg b. w of normal saline). The inhibitoryeffect of the extract was dose-dependent and comparable to that of the reference anti-inflammatory drug, indomethacin (0.3 mg/kg b. w).Conclusion: The data indicate that the ethanol extract of the stem bark of A. boonei possessesremarkable inhibitory effect on leucocyte migration and therefore, justifies the traditionaluse of the stem bark of A. boonei as an anti-inflammatory agent.Copyright a 2013, JPR Solutions; Published by Reed Elsevier India Pvt. Ltd. All rightsreserved. |
| Databáze: | OpenAIRE |
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