New Insecticidal Rocaglamide Derivatives from the Roots of Aglaia duperreana
| Autor: | L. Witte, L. C. Kiet, F. I. Bohnenstengel, B. W. Nugroho, P. D. Hung, C. Schneider, Chaidir, V. Wray, P. Proksch, J. Hiort |
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| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
Meliaceae biology medicine.drug_class Stereochemistry Organic Chemistry Substituent Absolute configuration Pharmaceutical Science Ether Carboxamide biology.organism_classification Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Rocaglamide Drug Discovery medicine Molecular Medicine Organic chemistry Phenols Spodoptera littoralis |
| Zdroj: | Journal of Natural Products. 62:1632-1635 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np990242g |
| Popis: | Bioassay-guided fractionation of an extract obtained from roots of Aglaia duperreana led to the isolation of 17 1H-cyclopenta[b]benzofurans of the rocaglamide type. Of the compounds isolated, four rocaglamide derivatives (2, 6, 11, and 16) were obtained as new natural products, and their structure elucidation was conducted by spectral methods. For bioassay-guided fractionation and determination of LC50 and EC50 values, neonate larvae of Spodoptera littoralis were employed. The results of chronic feeding assays have shown new aspects of the structure−activity relationship of rocaglamide derivatives. The substitution of a hydroxyl group at C-8b by a methoxyl substituent leads to a loss of insecticidal activity in a manner not previously documented in this compound class. |
| Databáze: | OpenAIRE |
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