Synthesis and Characterization of some 2-Azetidinones Derived from 3-Nitro Phthalic Anhydride and Evaluation their Biological against Bacteria and Fungi
| Autor: | Rabiha Hameed Saleh, Omar Abdulrahman Mohammed, Ahmood Kh. Jebur Al-Joubory |
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| Rok vydání: | 2020 |
| Předmět: |
010302 applied physics
Phthalic anhydride Materials science biology Mechanical Engineering 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics biology.organism_classification 01 natural sciences Characterization (materials science) chemistry.chemical_compound chemistry Mechanics of Materials 0103 physical sciences Nitro Organic chemistry General Materials Science 0210 nano-technology Bacteria |
| Zdroj: | Materials Science Forum. 1002:360-368 |
| ISSN: | 1662-9752 |
| DOI: | 10.4028/www.scientific.net/msf.1002.360 |
| Popis: | Reaction of the moiety 3-nitro phthalic anhydride with p- Phenylene diamine in (40 ml) acetic acid to give compound (p-amino phenyl)-3-nitro phthalimide (A1).Which that react with different aromatic aldehyde in ethanol absolute to give compounds hydrazone (A2-A5), then react this compounds (A2-A5) with chloro acetyl chloride in presence of TEA by using DMF as solvent to obtain 2-azetidinones (A6-A9).The compounds of all the newly synthesized structures were confirmed by and ,IR, 1H NMR as well as melting point. Some of these new structures showed antimicrobial activity (A7-A8) and anti-bacterial activity (A7-A8).Antibacterial activity of some prepared compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and E.coli (Gram negative). Some the compounds showed high inhibition activity against bacteria and two fungi (Candida albicans) and (Candida tropicalis.). |
| Databáze: | OpenAIRE |
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