The Ron receptor tyrosine kinase plays a protective role in the development of CNS inflammation during health and disease states

Autor:	Adwitia Dey, Joselyn N Allen, James W Fraser, Lindsay M Snyder, Margherita T Cantorna, Robert F Paulson, Pamela Hankey-Giblin
Rok vydání:	2017
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 198:206.10-206.10
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.198.supp.206.10
Popis:	Neurodegeneration is characterized by severe central nervous system (CNS) inflammation. Macrophages are immune cells that closely regulate inflammation by taking on different activation states. The Ron receptor tyrosine kinase is expressed on tissue resident macrophages including microglia. An in vivo deletion of Ron (Ron KO) promotes inflammatory (M1) and limits reparative (M2) macrophage activation. Whether this response influences CNS tissue inflammation is not characterized. The objective of this study was to elucidate whether Ron expression plays a critical role in CNS inflammation in homeostasis and subsequently in disease models. During homeostasis with no interventions, Ron KO mice developed an inflammatory CNS niche with increased tissue expression of M1-associated markers TNFα, Cox-2 and iNOS when compared to WT-mice (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6933a42ae7196f6ba4b8c2691a968857 https://doi.org/10.4049/jimmunol.198.supp.206.10 Zobrazit plný text záznamu