Response of Liver Metastases After Treatment with Yttrium-90 Microspheres: Role of Size, Necrosis, and PET
| Autor: | Jie Huang, Frank H. Miller, Jianhua Jin, Mary F. Mulcahy, Riad Salem, Ana L. Keppke, Denise Reddy |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Necrosis medicine.diagnostic_test business.industry medicine.medical_treatment Brachytherapy Interventional radiology General Medicine medicine.disease Metastasis Lesion Positron emission tomography Response Evaluation Criteria in Solid Tumors medicine Cholecystitis Radiology Nuclear Medicine and imaging Radiology medicine.symptom Nuclear medicine business |
| Zdroj: | American Journal of Roentgenology. 188:776-783 |
| ISSN: | 1546-3141 0361-803X |
| Popis: | OBJECTIVE. Yttrium-90 radioembolization is an emerging treatment for liver malignancies. The purpose of this study was to evaluate the imaging response of liver metastases to 90Y microspheres based on size and necrosis criteria using CT and comparing the results to PET and to describe imaging features related to 90Y therapy.MATERIALS AND METHODS. We reviewed the imaging studies of 42 patients with unresectable liver metastases treated with lobar radioembolization with 90Y. CT response was determined using traditional size criteria (World Health Organization [WHO] and Response Evaluation Criteria in Solid Tumors [RECIST]), necrosis criteria, and combined criteria (RECIST and necrosis). We compared the response on CT with the response on PET. Complications of treatment were assessed.RESULTS. The response rate was 19% (8/42) by WHO criteria, 24% (10/42) by RECIST, 45% (19/42) by necrosis criteria, and 50% (21/42) by combined criteria. Stabilization of lesion size occurred in 50% of patients. Necrosis and com... |
| Databáze: | OpenAIRE |
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