Apoptotic death ligands and interleukins in the vitreous of diabetic patients

Autor:	Winfried Graninger, L. M. Maier, Andreas Wedrich, E.-M. Haller-Schober, Richard Maier, Yosuf El-Shabrawi, Martin Weger, Ulrike Demel, Berthold Huppertz, Anton Haas, A. Theisl
Rok vydání:	2010
Předmět:	Lymphotoxin alpha medicine.medical_specialty business.industry Interleukin Diabetic retinopathy medicine.disease Fas ligand Pathogenesis Ophthalmology Endocrinology Apoptosis Internal medicine Diabetes mellitus Medicine Tumor necrosis factor alpha business
Zdroj:	Spektrum der Augenheilkunde. 24:305-310
ISSN:	1613-7523 0930-4282
DOI:	10.1007/s00717-010-0446-2
Popis:	BACKGROUND: To investigate the role of apoptosis in the pathogenesis of diabetic retinopathy we determined vitreous concentrations of Fas ligand (FasL), tumor necrosis factor alpha (TNF-α), lymphotoxin alpha (LT-α) and interleukin 1beta (IL-1β) in diabetic patients and non-diabetic control subjects. MATERIAL AND METHODS: In the present case-control study measurement of vitreous concentrations of the four apoptosis-related factors FasL, TNF-α, LT-α and IL-1β was performed using Cytometric Bead Array technology in 48 patients with diabetes mellitus (8 non-insulin dependent, 40 insulin dependent) and 24 non-diabetic control subjects. RESULTS: FasL, TNF-α, LT-α and IL-1β were not detectable in the vitreous of neither diabetic nor non-diabetic controls samples. CONCLUSION: This study suggests that there is no up-regulation of FasL, TNF-α, LT-α and IL-1β in the vitreous of diabetic patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::692ee2d22fd50eae13225a97ca2dc40e https://doi.org/10.1007/s00717-010-0446-2 Zobrazit plný text záznamu Full text from SpringerLink