ChemInform Abstract: Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol

Autor:	Daichi Nakamura, Yusuke Yasui, Yujiro Hayashi, Hiroaki Chiba, Kotaro Iwasaki
Rok vydání:	2016
Předmět:	chemistry.chemical_classification Dichloroacetaldehyde Aldol reaction Chemistry Yield (chemistry) Organic chemistry General Medicine Aldehyde Catalysis
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201649067
Popis:	The asymmetric cross-aldol reaction of dichloroacetaldehyde with aldehyde pronucleophiles proceeds in the presence of a trifluoromethyl-substituted diarylprolinol to afford γ,γ-dichloro-β-hydroxy aldehydes in good yield with excellent enantioselectivity. The obtained products are useful synthetic intermediates; they were successfully converted to form chiral alkynes and dichloroalkenes.
Databáze:	OpenAIRE
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