| Popis: |
The destruction of intestinal barrier plays an important role in the pathogenesis of UC. The anti-inflammatory, anti-oxidation, anti-apoptosis and anti-bacterial effects of DHM have been concerned. However, the effect of DHM on Intestinal Barrier Function remains unclear. In this study, we found that DHM protected intestinal barrier from DSS through suppressing inflammatory cell infiltration and restoring the expression of Tight junction proteins (TJs) occluding and ZO-1. Meanwhile, DHM reduced cell apoptosis in the gut by influencing the expression of Bcl-2 and Caspase3. FITC-dextran leakage and gut microbiota viability experiments were used to tested the protective effect of DHM on intestinal barrier intact. Therefore, DHM may have great therapeutic potential as a new drug for UC. |
