Effect of benzyl-1,3-benzodioxole derivatives on juvenile hormone binding by components of the hemolymph from the mediterranean fruit fly, Ceratitis capitata wiedemann
| Autor: | Franklin Chang, Eric B. Jang, Hsu Chiou-Ling, Leonard Jurd |
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| Rok vydání: | 1991 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology Stereochemistry Immunology Methoprene Biological activity Ceratitis capitata biology.organism_classification Dissociation constant chemistry.chemical_compound Endocrinology chemistry Internal medicine Hemolymph Juvenile hormone medicine Vitellogenesis Mode of action |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 99:15-20 |
| ISSN: | 0306-4492 |
| DOI: | 10.1016/0742-8413(91)90068-5 |
| Popis: | 1. Competitive displacement assays showed the presence of a single saturable high-affinity binder for JH III in hemolymph from adult female C . capitata . 2. The dissociation constant K d and total binding capacity B max for the binder were 0.93 × 10 −7 M and 7.46 nmol/mg protein respectively. 3. The order of affinity of JH homologs and an analog for the hemolymph binder was JH III > JH II > JH I > (7S)methoprene. 4. Three benzyl-1,3-benzodioxole derivatives (BBDs), coded J2581, J2710, and J3263, were ineffective in blocking JH III binding to hemolymph components. 5. The relationship between BBDs, vitellogenesis, and hemolymph binders and a proposed mode of action of BBDs are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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