Studies in the indole series. Part VI. Tetrahydropyrimido[3,4-a]indoles and isotryptamines

Autor:	A. Cohen, B. Heath-Brown, C. J. Cattanach
Rok vydání:	1971
Předmět:	Indole test Chemistry Yield (chemistry) Organic Chemistry Organic chemistry Mannich reaction
Zdroj:	Journal of the Chemical Society C: Organic. :359
ISSN:	0022-4952
DOI:	10.1039/j39710000359
Popis:	Fischer cyclisation of phenylhydrazones of 1,3-disubstituted 4-piperidones leads, in general, to both tetrahydropyrimido[3,4-a]indoles and 3-substituted 2-(2-alkylaminoethyl)indoles (isotryptamines). The latter can also be synthesised in low yield from 3-substituted 2-methylindoles by the Mannich reaction. They are cyclised to tetrahydropyrimido[3,4-a]indoles by treatment with aldehydes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6910fa56278882b32f986ce8f70a6444 https://doi.org/10.1039/j39710000359 Zobrazit plný text záznamu