Synthesis of 4-benzylidene-oxazol-5(4H)-imines, structural analogs of PK11195, under Bischler-Napieralski conditions

Autor:	Marco A. Almaraz-Girón, Alfredo Vázquez
Rok vydání:	2017
Předmět:	Diffraction 010405 organic chemistry Chemistry Microwave heating Organic Chemistry Drug Discovery 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Single crystal 0104 chemical sciences
Zdroj:	Tetrahedron Letters. 58:785-788
ISSN:	0040-4039
Popis:	A simple and convenient one-pot procedure to prepare 4-benzylidene-2-aryl-1,3-oxazol-5(4H)-imines from phenyl pyruvic acid and a series of arylamides, under classical Bischler-Napieralski (B-N) conditions and microwave heating (MW) has been developed. The structures of the prepared compounds were unambiguously assigned through single crystal X-ray diffraction studies. The compounds thus prepared can be used to synthesize bioactive compounds with different molecular architectures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::68fb03d623433ff995456e9f20a9de7b https://doi.org/10.1016/j.tetlet.2017.01.047 Zobrazit plný text záznamu Full Text from ScienceDirect