Association between AXIN1 gene polymorphisms and epithelial ovarian cancer in Chinese population
| Autor: | Yanyun Wang, Yaping Song, Min Su, Kai Li, Wei Wang, Yan Zhang, Di You, Bin Zhou, Qin Li, Xingming Huang |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty endocrine system diseases business.industry Biochemistry (medical) Clinical Biochemistry Single-nucleotide polymorphism 030204 cardiovascular system & hematology female genital diseases and pregnancy complications 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Drug Discovery AXIN1 Genotype medicine Epithelial ovarian cancer Gene polymorphism Allele business Gene Survival analysis |
| Zdroj: | Biomarkers in Medicine. 13:445-455 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2018-0306 |
| Popis: | Aim: The study was aimed to explore the association between AXIN1 gene polymorphism and epithelial ovarian cancer (EOC) susceptibility as well as prognosis. Methods: A total of 165 EOC cases and 327 healthy controls were recruited to participate in this study. In total three tag SNPs in AXIN1 gene were genotyped using PCR-restriction fragment length polymorphism. Results: Significantly increased EOC risk was found associated with the A/C heterozygous genotype of rs12921862, the C allele and C/T genotype in the rs1805105 and the T/T genotype of rs370681. Meanwhile, Kaplan–Meier survival curves showed that patients with rs12921862 C/C genotype improved overall survival in the EOC group. Conclusion: Our results suggest that the AXIN1 gene may be related to susceptibility and overall survival in EOC. |
| Databáze: | OpenAIRE |
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