Estrogen/estrogen receptor action and the pregnant myometrium
| Autor: | Pancharatnam Jeyasuria, Jennifer C. Condon, Prashanth Anamthathmakula, Chandrashekara Kyathanahalli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Physiology medicine.drug_class medicine.medical_treatment Estrogen receptor 03 medical and health sciences Insulin-like growth factor 0302 clinical medicine Physiology (medical) Internal medicine medicine Receptor Pregnancy business.industry Myometrium Hyperplasia medicine.disease 030104 developmental biology Endocrinology Estrogen business Estrogen receptor alpha hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Physiology. 13:135-140 |
| ISSN: | 2468-8673 |
| DOI: | 10.1016/j.cophys.2019.10.017 |
| Popis: | Estrogen and estrogen action in the myometrium are necessary for a successful pregnancy. Estrogen is required for both the myometrial hyperplastic phase of gestation as well as the contractile response that leads to parturition at term. The excessive levels of circulating estrogens during pregnancy, pose a signalling conundrum. How do different tissues that have varying spatial and temporal needs for estrogen deal with this high estrogen ligand level? Insulin like growth factor (IGF1) and its receptor are important to the process of hyperplasia and are estrogen responsive. Although IGF1 is necessary for a successful pregnancy, myometrial production of IGF1 seems to be redundant for myometrial expansion. This review discusses the newly investigated functionality of estrogen receptor alpha splice isoforms in uterine myometrial contractility and quiescence while also covering the role of estrogen and IGF1 in uterine myometrial hyperplasia during pregnancy. |
| Databáze: | OpenAIRE |
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