Effect of Mesterolone* on Plasma L.H., F.S.H. and Testosterone

Autor: A.E. Stocks, J.M. Poynting, Thomas Mj, Gordon Rd
Rok vydání: 2009
Předmět:
Zdroj: Andrologia. 7:287-296
ISSN: 1439-0272
0303-4569
DOI: 10.1111/j.1439-0272.1975.tb00942.x
Popis: An attempt to determine the effect of mesterolone on plasma luteinizing hormone (LH) follicle stimulating hormone (FSH) and testosterone levels is reported. Subjects were 4 normal 23-45 year old males. Each was given 50 mg mesterolone orally 3 times a day for 4 weeks. The full effect of the drug was obtained in 1 week. To show that gonadotropins could be suppressed in these subjects 17alpha-methyl testosterone was given in doses of 25 mg orally 3 times a day for 1 week. Suppression was shown. Also 2 hypogonadal patients with elevated gonadotropin levels were treated with both 17alpha-methyl testosterone or mesterolone for 5 months. Plasma samples were collected at monthly intervals. In another patient with delayed puberty the same treatment with 17alpha-testosterone was given for 9 months followed by mesterolone 25 mg 3 times a day for the next 9 months. Plasma LH and FSH were measured during treatment and for 10 months afterward. Of the 4 normal subjects 2 who were given mesterolone showed significant suppression of gonadotropins 1 showing suppression of both LH and FSH and the other of FSH only (p less than .01). In the other 2 normal subjects there were significant falls in plasma testosterone but plasma LH and FSH were not suppressed (p less than .05). In the hypogonadal patients only administration of 17alpha-methyl testosterone resulted in a satisfactory clinical response. Serial sampling of blood during therapy showed suppression of plasma LH and FSH. Signs of androgen activity were significantly greater with the 17alpha-methyl testosterone treatment than with mesterolone. It is concluded that mesterolone is a weak androgen.
Databáze: OpenAIRE
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