The pharmacokinetics of a single dose of artemisinin in subjects with liver cirrhosis
| Autor: | Peter J. Vries, Nguyen Xuan Khanh, Tran Khac Dien, Le Nguyen Binh, Nguyen Thi Yen, Dao Dinh Due, Chris J. Boxtel, Piet A. Kager, Bob Berg, Jan Butter, Bui Hien, R. Koopman, Els Portier, Pham Song, Nguyen Cam Thach |
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| Rok vydání: | 1997 |
| Předmět: |
Chemotherapy
Cirrhosis Absorption time business.industry medicine.medical_treatment Public Health Environmental and Occupational Health Pharmacology medicine.disease Liver disease First pass effect Infectious Diseases Pharmacokinetics parasitic diseases medicine Parasitology Biological half-life Artemisinin business medicine.drug |
| Zdroj: | Tropical Medicine & International Health. 2:957-962 |
| ISSN: | 1360-2276 |
| DOI: | 10.1046/j.1365-3156.1997.d01-155.x |
| Popis: | Artemisinin is mainly eliminated by hepatic transformation. To investigate whether the clearance of artemisinin in patients with liver cirrhosis is different from healthy volunteers, a pharmacokinetic study was performed in male Vietnamese patients with Child B cirrhosis of the liver who received 500 mg of artemisinin orally. The results were compared to those found in a previous study in healthy subjects. The mean (+/- SD) area under the concentration time curve was 2365 (+/- 1761) h ng/ml; the mean (+/- SD) clearance, 382 (+/- 303)L/h. The elimination half life was 4 (+/- 1.3) h extimated by log-linear regression and 2.4 +/- 0.9 h estimated by non-linear regression using a one-compartment first order elimination model. The mean (+/- SD) absorption time was 1.55 (+/- 0.8) h. These results were not different from the results of healthy subjects and show that liver disease has no effect on the availability and clearance of oral artemisinin, indicating that artemisinin has an intermediate hepatic extraction ratio and that there is no significant first pass effect. |
| Databáze: | OpenAIRE |
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