Phytochemical Investigation of Anti-plasmodial Metabolites from Brazilian NativePiperSpecies
| Autor: | Renata Cristina de Paula, Elsie F. Guimarães, Leosvaldo S. M. Velozo, Maria Auxiliadora Coelho Kaplan, Maria Fernanda Alves do Nascimento, Ana Clarissa C. Peixoto, Luciana Ferreira Soares, André M. Marques |
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| Rok vydání: | 2015 |
| Předmět: |
Piper
biology Traditional medicine Organic Chemistry Plasmodium falciparum Piperaceae biology.organism_classification medicine.disease Biochemistry Analytical Chemistry law.invention chemistry.chemical_compound chemistry Phytochemical Linalool law parasitic diseases Botany medicine Malaria Essential oil Nerolidol |
| Zdroj: | Journal of Essential Oil Bearing Plants. 18:74-81 |
| ISSN: | 0976-5026 0972-060X |
| DOI: | 10.1080/0972060x.2014.974075 |
| Popis: | The World Health Organization estimates there are 300 and 500 million new cases of malaria worldwide, every year, mostly in Africa, Asia, South Pacific Islands and South America. New efforts to search for novel drugs for treating malaria remain important in countries like Brazil, where many endemic areas still exist. The Amazonia region is responsible for more than 97 % of the malaria cases in the country. Two Piper species were chemically investigated in order to identify new anti-plasmodial plant secondary metabolites. The crude extract and sub-fractions from leaves of Piper lucaeanum were previously assayed against a resistant strain of Plasmodium falciparum. Hydrodistillation of the leaf essential oils (EO) from Piper lucaeanum and Piper claussenianum were analyzed by GC-MS. The main constituents found from P. lucaeanum leaf oil were α-pinene (30.0 %), α-zingiberene (30.4 %), β-sesquiphelandrene (11.1 %), β-bisabolene (8.9 %), while from P. claussenianum inflorescences oil nerolidol (23.7 %) a... |
| Databáze: | OpenAIRE |
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