ChemInform Abstract: 5(10→9)Abeo-ergoline Derivatives: Synthesis, 5-HT1A-Receptor Affinity and Selectivity

Autor:	Sergio Mantegani, Mario Varasi, Robert A. McArthur, Luca Baumer, Enzo Brambilla, M. G. Fornaretto, Carla Caccia
Rok vydání:	2010
Předmět:	Indole test chemistry.chemical_compound chemistry Stereochemistry Substituent medicine 5-HT1A receptor General Medicine Selectivity Receptor Ergoline medicine.drug
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
Popis:	The synthesis and the structure-affinity relationship (S.A.F.I.R.) study for the 5-HT 1A receptor sites of a novel series of 5(10→9) abeo -ergoline derivatives are presented. Most derivatives showed moderate to high affinity and selectivity for 5-HT 1A receptor sites. The structure-affinity relationship pointed out the role of the substituent at position 8, and the outstanding importance of the reduction of the indole 2,3-double bond for achieving the highest 5-HT 1A affinity and selectivity within the compounds presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::68d573adb2bed621532889c1dd001db7 https://doi.org/10.1002/chin.199837246 Zobrazit plný text záznamu Plný text