Daclizumab induction/tacrolimus sparing: a randomized prospective trial in renal transplantation
| Autor: | T M Sasaki, Deneen Fowlkes, Reza Ghasemian, Jimmy A. Light, Diana Y. Barhyte |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Transplantation
medicine.medical_specialty business.industry Lymphocyte chemical and pharmacologic phenomena Mycophenolate Gastroenterology Tacrolimus Surgery surgical procedures operative Daclizumab medicine.anatomical_structure Prednisone Internal medicine Toxicity medicine Adverse effect business medicine.drug |
| Zdroj: | Clinical Transplantation. 16:30-33 |
| ISSN: | 0902-0063 |
| DOI: | 10.1034/j.1399-0012.16.s7.4.x |
| Popis: | Tacrolimus inhibits lymphocyte responses by blocking calcium-dependent signalling pathways important in IL-2 generation. Daclizumab, a humanized monoclonal antibody, binds with high affinity to the Tac subunit of the IL-2receptor complex. We reasoned therefore that the absence of IL-2R should permit lower doses of tacrolimus and thereby less toxicity. Twenty-eight patients were randomized and followed for 6 months: Group 1, high dose (HD) tacrolimus (trough 12-17 ng/mL; n = 13); Group 2, low dose (LD) tacrolimus (trough 5-10 ng/mL; n = 15). All patients received daclizumab induction (2 mg/kg) on days 0 and 14, mycophenolate mofetil (2 g/d except for one patient who received 1 g) and rapid prednisone taper. Serious infections were minimal in both groups. Hospitalizations, for various reasons, were HD (n = 12) and LD (n = 6). All patients and grafts survived for the 6-month study period. There was one rejection episode in a non-compliant patient at 101 d. LD tacrolimus appears equally effective as HD tacrolimus in preventing rejection episodes and may be associated with fewer adverse events. |
| Databáze: | OpenAIRE |
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