Antibiotikaprophylaxe bei Sectio Caesarea - Piperacillin 4 g versus Piperacillin/Tazobactam 4,5 g

Autor:	Schindler Ae, K. J. Wagner, Bier U, Regidor Pa, Callies R
Rok vydání:	2006
Předmět:	Pregnancy business.industry Obstetrics and Gynecology medicine.disease Tazobactam Penicillin Pharmacotherapy Anesthesia Piperacillin/tazobactam polycyclic compounds medicine Antibiotic prophylaxis business Adverse effect Piperacillin medicine.drug
Zdroj:	Zentralblatt für Gynäkologie. 128:149-152
ISSN:	1438-9762 0044-4197
Popis:	INTRODUCTION Antibiotic prophylaxis is a standard procedure in obstetric surgery and has been discussed in various investigations. Use of treatment is judged by high efficacy and good tolerance. METHOD In 300 patients undergoing cesarean sections we compared results of application of Piperacillin 4 g and Piperacillin/Tazobactam 4.5 g after cut of umbilical cord. Tazobactam/Piperacillin is a combination of a broad-spectrum penicillin and a beta-lactamase inhibitor with increased toxicity against staph. aureus, enterobacter, and other germs responsible for local and systemic infections in obstetric surgery. RESULTS We did not observe any severe adverse effects. Rate of severe wound infections was 1.3 % (Tazobactam/Piperacillin) and 2 % (Piperacillin alone). The difference showed no statistic significance (p > 0.01). During postoperative course we found a higher increase of CRP (p < 0.01) in the Piperacillin group. CRP proved to be a useful objective parameter to distinguish between patients with or without postoperative infections. No differences were found in the number of leucocytes, time in hospital and other parameters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::68c2dc1870abbd98268ad7efe8f10a2b https://doi.org/10.1055/s-2005-872566 Zobrazit plný text záznamu