Synthesis of biotinylated 18β-glycyrrhetinic acid and its effect on tumor cells activity

Autor:	Jun-hua Shi, Dongzhi Wei, Jun-hua Xiao
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Biotin chemistry Biochemistry Cell culture Biotinylation Organic Chemistry Tumor cells General Pharmacology Toxicology and Pharmaceutics Cytotoxicity High-performance liquid chromatography In vitro Derivative (chemistry)
Zdroj:	Medicinal Chemistry Research. 18:538-544
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-008-9147-7
Popis:	18β-Glycyrrhetinic acid (GA) is the active component in licorice root. Recent study has shown that GA exhibits many pharmacological activities. Here a new derivative of GA, biotinylated GA (BGA), was synthesized by introducing the biotin to the C-29 carboxyl of GA, and its antitumor effects were confirmed through tests on mouse B16 melanoma cells and BEL 7402 human hepatocarcinoma cells. At the same time, it is shown that the biotin group in BGA has no influence on the antitumor effects of GA. Then the stability of BGA in Roswell Park Memorial Institute (RPMI) medium 1640 and water was determined by high-performance liquid chromatography (HPLC), demonstrating much greater stability than GA in these two liquids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::68bc40a4da5d569ea1c6454488d510e0 https://doi.org/10.1007/s00044-008-9147-7 Zobrazit plný text záznamu Full text from SpringerLink