Blepharitis: A Review on Human Clinical Trials with Synthetic and Natural Remedies

Autor:	Vyshma Kizhuppully Viswambaran, Gayathri Rajeev, Anavadhya K. A, Gopika Chandrababu, Swati Gupta, Amritha Babu
Rok vydání:	2020
Předmět:	0301 basic medicine Pharmacology medicine.medical_specialty business.industry medicine.disease Dermatology Clinical trial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030221 ophthalmology & optometry medicine Blepharitis business
Zdroj:	Biomedical and Pharmacology Journal. 13:1939-1945
ISSN:	2456-2610 0974-6242
DOI:	10.13005/bpj/2072
Popis:	Blepharitis is an eyelid disorder characterized by inflammation and pain. It affects all the ages and ethnic groups. Primary cause of blepharitis is poor hygienic condition. Topical antibiotics are the preferred first line therapeutic agents along with eyelid cleansing and warm compresses are recommended. Topical steroids, oral antibiotics and calcineurin inhibitors are also recommended in severe conditions. However, recurrence of disease, dose related side effects and safety regimen are still uncertain with these agents. Blepharitis needs a long term treatment, thus novel formulations and products with natural components may be considered more reliable to overcome such issues. In this review article we have discussed human clinical trials (HCTs) conducted with conventional synthetic drugs, novel drug delivery systems developed with synthetic drugs and drugs of natural origin and other supportive measures. As compared to synthetic drugs, formulations with natural origin were found to be safe with minimum side effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::68b7220b1f1190b0d1779f52b87df263 https://doi.org/10.13005/bpj/2072 Zobrazit plný text záznamu