| Autor: |
Vallet H, Emma Gostick, Justin J. Frere, Eleonora Gallerani, Appay, Riccardo Gavioli, David Price, Jacques Boddaert, Dubois M, Cabral-Piccin Mp, Sian Llewellyn-Lacey, Antonella Caputo, Laura Papagno, Francesco Nicoli, Antoine Toubert, Emmanuel Clave, Folcher |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
BackgroundAging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered antigens. The mechanisms that underlie this phenomenon have nonetheless remained unclear.MethodsBiochemical and functional properties of naive CD8+ T cells were characterized and compared between middle aged and older individuals.FindingsWe identified an age-related link between altered basal lipid metabolism in naive CD8+ T cells and their impaired responsiveness to stimulation, characterized by low proliferative potential and susceptibility to apoptosis. Reversal of the bioenergetic anomalies with lipid-altering drugs, such as rosiglitazone, improved the functional capabilities of naive CD8+ T cells in elderly subjects.InterpretationInterventions that favor lipid catabolism may find utility as adjunctive therapies in the elderly to promote vaccine-induced immunity against emerging pathogens or tumors.FundingA full list of the funding sources is detailed in the Acknowledgment section of the manuscript.RESEARCH IN CONTEXTEvidence before this studyOld subjects are highly susceptible to infections and tumors and usually present with low responses to vaccine. This is mainly due to the age-related loss of primary immune resources, i.e. a quantitative decline of naive CD8+ T cells. Nonetheless, few studies have also underlined, within this cell subset, qualitative defects in elderly subjects.Added value of this studyConsidering the well-demonstrated link between nutrient usage and lymphocyte functions, we characterized the bioenergetics features of old naïve CD8+ T cells. Our data show an age-dependent altered basal metabolism in this cell subset, mostly at the levels of fatty acids and mitochondrial functions. These alterations were associated with functional defects which were partially reverted through the use of lipid-lowering strategies.Implications of all the available evidenceThis study highlights the potential role of an altered cellular lipid metabolism in immunosenescence, providing clues to understand the epidemiological profile of emerging infections or tumors and to develop preventive and therapeutic strategies based on metabolic manipulation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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