Effect of complete response pre- and post- autologous stem cell transplantation in multiple myeloma

Autor:	F. Sayani, Nizar J. Bahlis, Ahsan Chaudhry, Douglas A. Stewart, M. L. Savoie, Peter Faris, James A. Russell, Christopher D. Brown, L. Kmet
Rok vydání:	2006
Předmět:	Oncology Cancer Research medicine.medical_specialty business.industry medicine.disease High dose therapy Autologous stem-cell transplantation Internal medicine medicine Stem cell business Pre and post Multiple myeloma Complete response
Zdroj:	Journal of Clinical Oncology. 24:7604-7604
ISSN:	1527-7755 0732-183X
Popis:	7604 Background: The value of achieving a complete response (CR) pre or post high dose therapy and autologous stem cell transplant (HDT-ASCT) in multiple myeloma is still uncertain. Knowing the impact of achieving a CR prior to HDT-ASCT on survival, may lead to the incorporation of novel therapeutic agents into the front line treatment of this disease. The aim of our study was to determine whether achieving a CR before or after HDT-ASCT affects overall survival (OS) in multiple myeloma patients. Methods: We performed a retrospective analysis of 88 consecutive myeloma patients receiving HDT-ASCT at our center from 1993 to 2004. The OS of patients achieving at least 90% reduction in their M-protein, i.e. complete response and very good partial response (CR/VGPR), pre or post HDT-ASCT, was compared to that of patients achieving a partial response or less ( No significant financial relationships to disclose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::68b3920eac3525f0ec934d566ef70f8c https://doi.org/10.1200/jco.2006.24.18_suppl.7604 Zobrazit plný text záznamu