Cardiovascular Diseases and Periodontal Disease
| Autor: | Maude Leclerc, Thomas T. Nguyen, Simon D. Tran, Kevin Y. Wu, Hieu M. Pham |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Periodontitis medicine.medical_specialty business.industry Inflammation 030206 dentistry Disease Periodontium Bioinformatics medicine.disease Periodontal bacteria Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immunology and Microbiology (miscellaneous) Periodontal disease Epidemiology Medicine Surgery Oral Surgery medicine.symptom business |
| Zdroj: | Current Oral Health Reports. 5:13-18 |
| ISSN: | 2196-3002 |
| Popis: | Periodontitis and cardiovascular diseases are both inflammatory conditions. Recent epidemiological studies have associated the effects of periodontitis on cardiovascular disease (CVD) progression. This review aims to summarize the relationship between those two conditions. Although there is no evidence of a causal relationship, an association between the two conditions is apparent. The potential factors include bacterial pathway, inflammation, and genetics. Periodontal bacteria affect endothelial cells through interactions that aggravate the atherogenic process. Ulcerated periodontium produces cytokines which increase the production of acute-phase proteins that have been associated with cardiovascular events. Genetic studies have demonstrated the presence of risk alleles in the genes ANRIL and CAMTA1/VAMP3 that are shared between these two diseases. This review discusses the current understanding of CVD pathogenesis, underlying mechanisms of periodontitis in CVD, and effects of periodontal therapy on CVD, and provides guidelines for treating patients with CVD risks in respect to periodontal disease. |
| Databáze: | OpenAIRE |
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