Novel and Efficient Synthesis of Deuterium-Labeled Olopatadine-d6

Autor:	Nareshvarma Seelam, Srinu Bodige, K. Ch. Gulipalli, Srinivas Endoori
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Alkylation Olopatadine 01 natural sciences Combinatorial chemistry 0104 chemical sciences Reagent Proton NMR medicine Amine gas treating Deuterium labeled Spectral data medicine.drug
Zdroj:	Russian Journal of Organic Chemistry. 55:1387-1393
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428019090197
Popis:	A novel and highly efficient synthetic approach has been developed for the synthesis of deuterium-labeled olopatadine-d6 using inexpensive and commercially available dimethyl sulfate-d6 at the stage of alkylation of primary amine intermediate. The proposed synthetic path makes it possible to avoid the use of expensive labeled reagents such as dimethyl amine-d6 used as labeled precursor in the traditional synthetic route. The structure of the obtained olapatadine-d6 has been confirmed by 1H NMR and mass spectral data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::68afa7c6203133cbc5b43790f9253610 https://doi.org/10.1134/s1070428019090197 Zobrazit plný text záznamu Full text from SpringerLink