Deficient levels of dietary selenium suppress the antibody response in first and second generation mice
| Autor: | A.R. Vessey, G.L. Taylor, Louise Magruder, Sally A. Mulhern |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics biology Ratón Endocrinology Diabetes and Metabolism medicine.disease Primary and secondary antibodies Endocrinology medicine.anatomical_structure Lymphatic system Immune system Antigen Selenium deficiency In vivo Internal medicine Lactation medicine biology.protein |
| Zdroj: | Nutrition Research. 5:201-210 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/s0271-5317(85)80036-1 |
| Popis: | The effect of a selenium-deficient diet during prenatal and postnatal development on the immune response was investigated in the C57BL/6J mouse. When the selenium-deficient diet was administered postweaning, these was no effect on the serum chemistries, primary antibody response, or lymphoid organ weight. However, the secondary antibody response to a T-cell dependent antigen was diminished. Administration of the selenium-deficient diet during gestation, lactation, and postweaning development had no effect on the serum chemistry values or lymphoid organs. However, body weights and primary and secondary antibody responses were reduced. Similar results were obtained in both in vivo and in vitro assay systems. |
| Databáze: | OpenAIRE |
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