Proteomic Analysis Reveals an Increase of Neutrophils and TH17-related Proteins Expression in Severe Nodular Acne Lesions of the Back
| Autor: | Corinne Ménigot, Bruno Mehul, Johannes Voegel, Alexia Seraidaris, Isabelle Carlavan, S. Blanchet‐Réthoré, Brigitte Dréno, Béatrice Bertino, V. Bourdès, Alexandre Genette |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry 020208 electrical & electronic engineering Elastase Lipid metabolism 02 engineering and technology Dermatology Proteomics medicine.disease Staining Immune system 0202 electrical engineering electronic engineering information engineering Etiology Medicine business Infiltration (medical) Acne |
| Zdroj: | Journal of Skin and Stem Cell. 6 |
| ISSN: | 2423-7086 |
| Popis: | Background: The etiology and different inflammatory steps associated with the development of an acne nodule remain unsolved. Objectives: This study aimed to investigate the main biological processes involved in acne nodules and compare them to those of papules. Methods: Nodules, papules, and non-involved skin of the back (control) were biopsied to perform proteomic analysis using mass spectrometry, Luminex assay, and elastase staining on skin sections. Results: Many factors involved in the migration and function of immune cells, particularly those impacting leukocytes and neutrophils, were strongly and significantly higher in nodules than in papules and non-involved skin, while several enzymes involved in lipid metabolism were lower. Elastase staining confirmed strong neutrophil infiltration within and around the nodules. Conclusions: Our results highlight the role of neutrophils during nodule formation in severe nodular acne of the back. |
| Databáze: | OpenAIRE |
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