Tranexamic acid reduces blood loss after off-pump coronary artery bypass grafting: a double blind placebo controlled study
| Autor: | David Bracco, Fadi Basile, Ignacio Prieto, Thomas M. Hemmerling, Tulika Shinghal, Nicolas Noiseux |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Antifibrinolytic medicine.drug_class business.industry medicine.medical_treatment Placebo-controlled study General Medicine Placebo Cardiac surgery Surgery Anesthesiology and Pain Medicine Anesthesiology Anesthesia medicine Aprotinin business Tranexamic acid Off-pump coronary artery bypass medicine.drug |
| Zdroj: | Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 54:44531-44531 |
| ISSN: | 1496-8975 0832-610X |
| Popis: | INTRODUCTION: The use of anti-fibrinolytics have been recently challenged in cardiac surgery (1). Aprotinin is effective in reducing blood loss but may carry some risks of anaphylactic reaction and postoperative complications. Tranexamic acid and amino caproic acid have weaker antifibrinolytic activities but seem not related to an increased risk of complications after cardiac surgery. However, one study has shown that in low risk for bleeding cardiac surgery, the use of tranexamic acid is no better than placebo in reducing significant blood loss (2). Off-pump aortocoronary bypass grafting (OPCAB) poses significantly less risk for bleeding in cardiac surgery in comparison to on-pump CABG. We therefore designed a pilot study investigating whether tranexamic acid significantly reduces blood loss after, performed in this hospital setting for 90% of all aortocoronary bypass grafting. |
| Databáze: | OpenAIRE |
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