AN ANALOGY OF HRCT CHEST AND ANTIGEN ASSAY WITH RT- PCR TEST IN THE DIAGNOSIS OF COVID-19

Autor: Janani Moorthy, Vasantha Kumar, Vinoth Thangam, Prabhu Radhan, Saranya Ayyadurai, Balasubramanyam Gadiraju, Rajani Rajani
Rok vydání: 2023
Předmět:
Zdroj: INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. :87-89
DOI: 10.36106/ijsr/6106281
Popis: Introduction We aim to compare Rapid Antigen Test and HRCT chest with Reverse Transcriptase-Polymerase chain reaction (RT-PCR) for diagnosis of COVID-19. MethodsThis observational cross-sectional analytical study included patients tested with RT- PCR and at least one Rapid Antigen test or HRCT chest, which was conducted at ACS Medical college Chennai, from June 2021 to June 2022 after obtaining the ethical clearance. Data analysis was done using statistical packages for social sciences version 16. Results 315 of 755(41.7%) patients had positive RTPCR and 18.4% of 733 patients had positive antigen tests. Of 600 patients, 106(14.0%) were found to have CO-RADS 1,152(20.1%) had CORADS 2, 77(10.2%) had CO-RADS 3, 18(2.4%) had CO-RADS 4 and 247(32.7%) had CO-RADS 5 score on HRCT. Rapid Antigen Test was found to have 43.6% sensitivity, 98.6% specicity, 95.6% Positive predictive value (PPV), and 72.1% negative predictive value (NPV).CO-RADS scoring system was able to distinguish between RT-PCR positive and RT-PCR negative results with an average Area under curve 0.787. CO-RADS 5 had a sensitivity of 71.6%, specicity of 85.1%, PPVof 80.6%, and NPVof 77.6% for a positive RT-PCR result. Acombination of CO-RADS 1 in HRCT chest and a Negative Antigen test can predict PCR negative results with 23.6% sensitivity, 97.3% specicity, 90.5% PPV, and 54.0% NPV. Conclusions Rapid Antigen Test is a better tool for conrmation rather than screening for COVID-19. HRCT chest with higher CO-RADS can be useful to diagnose COVID-19 in suspected patients, even if RT-PCR is negative.
Databáze: OpenAIRE
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