Stereotactic Body Radiotherapy Based on 99mTc-GSA SPECT Image-guided Inverse Planning for Hepatocellular Carcinoma
| Autor: | Tetsuo Saito, Tomohiko Matsuyama, Yudai Kai, Ryo Toya, Shinya Shiraishi, Yoshinobu Shimohigashi, Natsuo Oya, Yoshiyuki Fukugawa |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Re-Irradiation Cancer Research medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Single-photon emission computed tomography medicine.disease General Biochemistry Genetics and Molecular Biology Radiation therapy Liver disease Hepatocellular carcinoma medicine Radiology Liver function business Stereotactic body radiotherapy Emission computed tomography |
| Zdroj: | In Vivo. 34:3583-3588 |
| ISSN: | 1791-7549 0258-851X |
| Popis: | Background/aim A recent planning study suggested that 99mTc-labelled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) single-photon emission computed tomography (SPECT) image-guided inverse planning (IGIP) shows dosimetric superiority to conventional planning in sparing liver function. Here, we report the first clinical translation of 99mTc-GSA SPECT IGIP for stereotactic body radiotherapy (SBRT) in a patient with hepatocellular carcinoma (HCC). Case report A 60-year-old male developed obstructive jaundice caused by recurrent HCC in segment 1 after hepatic resection. He underwent repeated radiotherapy (RT) consisting of 45 Gy in 15 fractions 8 years ago and 30 Gy in 5 fractions 2 years ago. We performed SBRT consisting of 40 Gy in 8 fractions using 99mTc-GSA SPECT-IGIP. We confirmed the dosimetric superiority of functional IGIP to conventional planning. He achieved complete response as assessed using the target volume. The patient has remained alive without recurrence for 18 months. He did not experience radiation-induced liver disease. Conclusion Recurrent HCC was successfully and safely salvaged via re-irradiation with SBRT using 99mTc-GSA SPECT-IGIP. |
| Databáze: | OpenAIRE |
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