Copper-catalyzed tandem oxidative synthesis of quinazolinones from 2-aminobenzonitriles and benzyl alcohols

Autor: Bindong Li, Yongke Hu, Yanxing Li, Shaozhong Li, Huaju Li, Chuansong Duanmu, Jin Li
Rok vydání: 2019
Předmět:
Zdroj: Organic Chemistry Frontiers. 6:2744-2748
ISSN: 2052-4129
Popis: An efficient and practical copper-catalyzed process for the synthesis of substituted quinazolinones from simple and readily available 2-aminobenzonitriles and benzyl alcohols is described. This method features high functional-group tolerance and could afford a variety of desirable products in good to excellent yields with air as the sole oxidant. Moreover, a possible reaction mechanism is proposed according to the control experiments and reported literature.
Databáze: OpenAIRE