Radical prostatectomy outcomes during prostate-specific antigen era in Ireland compared to a matched American population
| Autor: | Stacy Loeb, Qiaoyan Hu, Phillip R. Cooper, Breffini Anglim, Andrew Fennell, William J. Catalona, Ted McDermott, Brian T. Helfand, Robert Flynn, John A. Thornhill, Barry B. McGuire, Ronald Grainger |
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| Rok vydání: | 2013 |
| Předmět: |
Gynecology
education.field_of_study medicine.medical_specialty medicine.diagnostic_test Prostatectomy business.industry Urology medicine.medical_treatment Population medicine.disease Prostate-specific antigen Prostate cancer medicine.anatomical_structure Prostate Internal medicine Biopsy medicine Surgery Stage (cooking) education business Pathological |
| Zdroj: | Journal of Clinical Urology. 7:170-175 |
| ISSN: | 2051-4166 2051-4158 |
| DOI: | 10.1177/2051415813496995 |
| Popis: | Objectives: To examine temporal trends in clinico-pathological outcomes following radical prostatectomy (RP) in Ireland over time, and perform matched comparison of between Ireland and the USA based upon initiation of prostate-specific antigen (PSA) screening. Methods: Between 2000–2010, 651 RPs were carried out at a single institution in Ireland. Clinic-pathologic tumor features were compared to 1302 men treated in the USA from the same time interval (matching on year of diagnosis, 1:2 ratio). As historical comparison, we included a separate group of 150 USA men who underwent RP during the early PSA era (1990–1992). Results: We observed a downward migration in biopsy tumor burden ( p=0.002), RP tumor volume ( pConclusions: During the past decade of increasing PSA utilization in Ireland, we found evidence of pathological stage migration. In comparison to a USA population, Irish men have worse pathological characteristics, however, in comparison to the early USA PSA era, Irish men are more likely to have organ-confined disease. |
| Databáze: | OpenAIRE |
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