Efficient Preparation of Imidazo[1,5-a]pyridine-1-carboxylic Acids

Autor:	Maksym O. Chekanov, Dmytro O. Tverdiy, Andrey A. Fokin, Anatolii R. Syniugin, Sergiy M. Yarmoliuk, Pavlo V. Savitskiy
Rok vydání:	2016
Předmět:	Bicyclic molecule 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry Cleavage (embryo) 01 natural sciences Catalysis 0104 chemical sciences Acylation chemistry.chemical_compound Pyridine Organic chemistry Trifluoroacetic anhydride
Zdroj:	Synthesis. 48:4269-4277
ISSN:	1437-210X 0039-7881
Popis:	We report a novel and efficient approach to the synthesis of imidazo[1,5-a]pyridine-1-carboxylic acids. By using the reaction of 2-(aminomethyl)pyridine with acyl chlorides followed by one-pot treatment with trifluoroacetic anhydride, 2,2,2-trifluoro-1-imidazo[1,5-a]pyridin-1-ylethanones were obtained, which were then converted into imidazo[1,5-a]pyridine-1-carboxylic acids in high preparative yields through haloform cleavage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::688e8e741525676e5650bf5ed10bae0c https://doi.org/10.1055/s-0035-1561489 Zobrazit plný text záznamu