Synthesis of corey lactone via highly stereoselective asymmetric diels-alder reaction

Autor:	Toshihiko Tsuruda, Arai Kazutaka, Miyaji Katsuaki, Takahashi Yasuhiro, Yoshio Ohara
Rok vydání:	1991
Předmět:	chemistry.chemical_classification Acrylate Bicyclic molecule Stereochemistry Organic Chemistry Biochemistry Adduct chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Organic chemistry Stereoselectivity Lactone Diels–Alder reaction
Zdroj:	Tetrahedron Letters. 32:4557-4560
ISSN:	0040-4039
DOI:	10.1016/0040-4039(91)80038-8
Popis:	We have succeeded in a highly stereoselective asymmetric Diels-Alder reaction between a chiral acrylate 3a derived from commercially available D-pantolactone 2 and 5-benzyloxymethyl-cyclopentadiene 4 to give the adduct 5a in 94% d.e. and 79% yield for the synthesis of Corey lactone 1 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::688e8be387e34ee17b303bcd68a1b879 https://doi.org/10.1016/0040-4039(91)80038-8 Zobrazit plný text záznamu