Highly Regioselective Synthesis of Novel 4-O-Phosphorylated Paeonol Analogs

Autor:	Yufen Zhao, Zhi-Yu Ju, Gong-Chun Li, Jie Wang, Yong Ye, Fengling Yang
Rok vydání:	2012
Předmět:	inorganic chemicals Reaction conditions Chemistry Organic Chemistry Regioselectivity chemistry.chemical_element Resorcinol Biochemistry Sulfur Inorganic Chemistry Acylation Acetic acid chemistry.chemical_compound Organic chemistry Paeonol
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 187:859-863
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426507.2011.627901
Popis:	4-O-phosphorylated paeonol derivatives were conveniently prepared by a facile method. Resacetophenone was prepared by the Friedel–Crafts acylation reaction of acetic acid with resorcinol. It was then phosphorylated regioselectively at the 4-O position using the Atherton–Todd reaction. An efficient, highly regioselective method to synthesize 4-O-phosphorylated paeonol derivatives is provided, and the approach has the merits of mild reaction conditions. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
Databáze:	OpenAIRE
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